Refrigerant Types Explained: Which One Is Right for Your Chiller System?
Common refrigerant types
Refrigerants can be divided into CFC, HCFC, HFC, HFO and natural refrigerants according to their molecular structure and chemical composition.

How to choose a refrigerant for a chiller system
You need to consider the choice of refrigerant based on the following factors:
Application scenarios
Medical and experimental equipment have high requirements for temperature control accuracy and stability. We usually recommend using R134a or R410A in these cooling systems. R407C and R32 are widely used in industrial cooling systems. HFO refrigerants and natural refrigerants are recommended for industries with high environmental requirements.
Working temperature
Refrigerants with low boiling points should be selected for low-temperature working environments. R23, R508B and mixed refrigerants are commonly used in ultra-low temperature chillers (below -40°C). We have designed R23 systems for low-temperature chemical reaction cooling projects. Although the cost is high, it still maintains stable water output at -70°C.
Environmental regulations
The EU F-Gas regulations and the US EPA SNAP regulations have restrictions on high GWP refrigerants. The refrigerants in cooling systems exported to these countries and regions need to comply with environmental regulations, otherwise they may face EPA label certification issues and be forced to extend delivery time.
Energy efficiency and cost
Many customers care about the initial cost, but we recommend that you give priority to whether the refrigerant is available for a long time, rather than facing the dilemma of being eliminated at any time in the next 10 years.
Eco-Friendly Refrigerants: The Future of Cooling
At present, the world is promoting the use of environmentally friendly refrigerants such as R32, R1234yf, CO₂ to replace the commonly used R22, R123, R134a, and R410A. From our order records, users in the EU, Japan, and North America prefer to choose low-GWP HFO or natural refrigerants. Whether the refrigerant is environmentally friendly has become a key factor affecting users’ purchasing decisions. Therefore, most chiller manufacturers support customized refrigerant types to meet market demand.
Conclusion
LNEYA provides cooling systems that are compatible with multiple refrigerants. If you don’t know how to choose, you can send your working conditions, usage areas, and budget to our team, and we will tailor a solution for you within 24 hours.
Let’s talk about your cooling needs.
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